<strong>Expression of p16 in Human Colorectal Cancer and Its Clinical Significance</strong>

doi:10.11910/2227-6394.2015.03.02.02

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Abstract Objective: To explore the expression of p16 in human colorectal cancer and its clinical significance. Methods: Neoplastic tissues and autologous non-neoplastic tissues were taken from 30 patients with colorectal cancer immediately after the operation. The expression of p16 in these tissues was detected using immunohistochemistry, and then was confirmed with HT-29 cell line by Western-blot assay. Results: The positive rate of p16 expression in neoplastic tissues was 23.3%, significantly lower than that in non-neoplastic tissues (P<0.01). p16 expression was closely associated with Dukes’ staging (P<0.01), lymph node metastasis(P<0.05) and histological differentiation degrees (P<0.05). And western-blot assay showed that the p16 expression in HT-29 cells was consistent with that of human colorectal cancer. Conclusion: Abnormal expression of p16 may play an important role in the occurrence and progression of colorectal cancer, and hence, it would be associated with the prognosis of colorectal cancer.

Key words： p16 Colorectal cancer Prognosis

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	HE Qian-qian

Cite this article:

HE Qian-qian. Expression of p16 in Human Colorectal Cancer and Its Clinical Significance[J]. Journal of International Translational Medicine, 2015, 3(2): 77-80.

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http://www.jitm.hk/EN/10.11910/2227-6394.2015.03.02.02 OR http://www.jitm.hk/EN/Y2015/V3/I2/77

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