<strong>Relationship between Polymorphism of HLA-DP Gene and Susceptibility Hepatitis C Infection</strong>

doi:10.11910/2227-6394.2015.03.02.06

Abstract
Figure/Table
References (14)
Related Citation (15)

Download: PDF (314 KB)
Export: BibTeX | EndNote (RIS)

Abstract

Objective: To assess the relationship between HLA-DP gene polymorphism and the susceptibility of HCV infection among high-risk populations in Jiangsu Province. Methods: Three HLA-DP variants of rs3077, rs9277535 and rs2395309 were genotyped in 1653 subjects including 268 self-limited HCV infection subjects, 401 persistent HCV infection subjects and 984 healthy control people using Taqman- MGB. Conclusion: These variants in the HLA-DP locus are associated with the susceptibility of HCV infection.Three HLA-DP variants of rs3077, rs9277535 and rs2395309 were genotyped in 1653 subjects including 268 self-limited HCV infection subjects, 401 persistent HCV infection subjects and 984 healthy control people using Taqman- MGB. Results: The frequencies of rs3077, rs9277535 and rs2395309 mutant genotype in HCV infected group were much higher than in control group (P_rs3077<0.010; P_rs9277535=0.043; P_rs2395309<0.010); The frequencies of rs3077 TC and rs2395309 AG heterozygous genotypes were much higher than control group (P_rs3077=0.033

Key words： HLA-DP Gene polymorphism Hepatitis C virus

Corresponding Authors: XIAO Rong-rong, Email: xiaorrong@126.com

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	WANG Jia
	XIAO Rong-rong
	SHEN Hong-bing

Cite this article:

WANG Jia,XIAO Rong-rong,SHEN Hong-bing. Relationship between Polymorphism of HLA-DP Gene and Susceptibility Hepatitis C Infection[J]. Journal of International Translational Medicine, 2015, 3(2): 98-102.

URL:

http://www.jitm.hk/EN/10.11910/2227-6394.2015.03.02.06 OR http://www.jitm.hk/EN/Y2015/V3/I2/98

1 Pol S, Vallet-Pichard A, Corouge M, et al. Hepatitis C: epidemiology, diagnosis, natural history and therapy. Contrib Nephrol, 2012, 176: 1-9.

2           Khedmat H Agah S In vitro evidence for association between hepatitis C virus infection and insulin signaling pathways: a review. Pak J Biol Sci,, 17(5): 601-7.  2014, Taheri S.,

3           Li L, Assanangkornchai S, Duo L, et al. Risk behaviors, prevalence of HIV and hepatitis C virus infection and population size of current injection drug users in a China-Myanmar border city: results from a Respondent-Driven Sampling Survey in 2012. PLoS One, 2014, 9(9): e106899.

4 Roughan JE, Reardon KM, Cogburn KE, et al. Chronic hepatitis C virus infection breaks tolerance and drives polyclonal expansion of autoreactive B cells. Clin Vaccine Immunol, 2012, 19(7): 1027-37.

5 Su CH, Lin Y, Cai L. Genetic factors, viral infection, other factors and liver cancer: an update on current progress. Asian Pac J Cancer Prev, 2013, 14(9): 4953-60.

6 Mueller M, Spangenberg HC, Kersting N, et al. Virus-specific CD4⁺ T cell responses in chronic HCV infection in blood and liver identified by antigen-specific up-regulation of CD154. J Hepatol, 2010, 52(6): 800-11.

7 Hong X, Yu RB, Sun NX, et al. Human leukocyte antigen class II DQB1*0301, DRB1*1101 alleles and spontaneous clearance of hepatitis C virus infection: A meta-analysis. World J Gastroenterol, 2005, 11(46): 7302-7.

8 Kuniholm MH, Kovacs A, Gao X, et al. Specific human leukocyte antigen class I and II alleles associated with hepatitis C virus viremia. Hepatology, 2010, 51(5): 1514-22.

9 Kang W, Sung PS, Park SH, et al. Hepatitis C virus attenuates interferon-induced major histocompatibility complex class I expression and decreases CD8⁺ T cell effector functions. Gastroenterology, 2014, 146(5): 1351-60.

10 Noguchi E, Sakamoto H, Hirota T, et al. Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations. PLoS Genet, 2011, 7(7): e1002170.

11 Vignal CM, Bansal AT, Balding DJ. Using penalized logistic regression to fine map HLA variants for rheumatoid arthritis. Ann Hum Genet, 2011, 75(6): 655-64.

12 Kamatani Y, Wattanapokayakit S, Ochi H, et al. A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians. Nat Genet, 2009, 41(5): 591-5.

13 Yu Z, Li Z, Jolicoeur N, et al. Aberrant allele frequencies of the SNPs located in microRNA target sites are potentially associated with human cancers. Nucleic Acids Res, 2007, 35(13): 4535-41.

14 Thanopoulou E, Kotzamanis G, Pateras IS, et al. The single nucleotide polymorphism g.1548A >G (K469E) of the ICAM-1 gene is associated with worse prognosis in non-small cell lung cancer. Tumour Biol, 2012, 33(5): 1429-36.