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Correlation Between Th1, Th2 Cells and Levels of Serum MMP-2, MMP-9 in Children with Asthma |
WANG Xuan, ZHANG Xi-rong, LI Gang |
Pediatric Inpatient, Gaoling Maternity and Child Healthcare Hospital, Xi’an, Shanxi, 610100, China |
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Abstract Objective: To explore the correlation between Th1 and Th2 cells and the levels of serum matrix metalloproteinase-2 (MMP-2) and MMP-9 in children with asthma. Methods: A total of 89 children with asthma were divided into acute group (n=48) and chronic group (n=41) according to the course of disease, and 40 healthy children at the same term were collected as control group. The ratios of Th1 and Th2 cells as well as levels of MMP-2 and MMP-9 were compared in three groups, and the correlation between Th1 and Th2 cells and levels of MMP-2, MMP-9 was analyzed in acute group and chronic group. Results: When compared with control group, the ratios of Th1 and Th2 cells went down in both acute group and chronic group (P<0.01), while the levels of serum MMP-2 and MMP-9 up (P<0.01). The levels of serum MMP-2 and MMP-9 in acute group were dramatically higher than those in chronic group, and there was statistical significance (P<0.01). Pearson correlation analysis revealed that there was no significant correlation between Th1 and Th2 cells and MMP-2 level (r=0.148, P=0.314, r=0.299, P=0.058; r=0.183, P=0.214, r=0.289, P=0.067), whereas both Th1 and Th2 cells were negatively correlated with MMP-9 level in acute group and chronic group (r=-0.489, P=0.000, r=-0.324, P=0.039; r=-0.352, P=0.014, r=-0.357, P=0.022). Conclusion: Aberrant secretion of Th cells can not only damage the immune function of children with asthma, but also decrease the level of serum MMP-9, consequently affecting the collagen degradation and airway remodeling.
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Corresponding Authors:
WANG Xuan: E-mail: mengxuewangxuan@163.com
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1 Normansell R, Walker S, Milan SJ, et al. Omalizumab for asthma in adults and children. Cochrane Database Syst Rev, 2014, 1: CD003559. doi: 10.1002/14651858. 2 Yamauchi K, Inoue H. Airway remodeling in asthma and irreversible airflow limitation-ECM deposition in airway and possible therapy for remodeling. Allergol Int, 2007, 56(4): 321-9. 3 Kaur M, Bell T, Salek-Ardakani S, et al. Macrophage adaptation in airway inflammatory resolution. Eur Respir Rev, 2015, 24(137): 510-5. 4 Kumar D, Kumar M, Saravanan C, et al. Curcumin: a potential candidate for matrix metalloproteinase inhibitors. Expert Opin Ther Targets, 2012, 16(10): 959-72. 5 Thomas PK. Guideline based management of bronchial asthma. J Assoc Physicians India, 2014, 62(3 Suppl): 27-31. 6 Li Y, Pan X, Peng X, et al. Adenovirus-mediated interleukin-35 gene transfer suppresses allergic airway inflammation in a murine model ofasthma. Inflamm Res, 2015, 64(10): 767-74. 7 Ablimit A, Hasan B, Lu W, et al. Changes in water channel aquaporin 1 and aquaporin 5 in the small airways and the alveoli in a rat asthma model. Micron, 2013, 45: 68-73. 8 Galera R, Casitas R, Martínez-Cerón E, et al. Does airway hyperresponsiveness monitoring lead to improved asthma control? Clin Exp Allergy, 2015, 45(9): 1396-405. 9 Pałgan K, Bartuzi Z. Angiogenesis in bronchial asthma. Int J Immunopathol Pharmacol, 2015, 28(3): 415-20. 10 Vinding RK, Stokholm J, Chawes BL, et al. Blood lipid levels associate with childhood asthma, airway obstruction, bronchial hyperresponsiveness, and aeroallergen sensitization. J Allergy Clin Immunol, 2015, doi: 10.1016/j.jaci.2015.05.033. 11 Li QG, Wang AP, Xia Y, et al. Effect of neurotrophin in the lung on airway hyperresponsiveness in the rats with bronchial asthma. Chinese Journal of Neuromedicine, 2012, 11(1): 31-6. 12 Gosens R, Grainge C. Bronchoconstriction and airway biology: potential impact and therapeutic opportunities. Chest, 2015, 147(3): 798-803. 13 Newby AC. Metalloproteinase expression in monocytes and macrophages and its relationship to atherosclerotic plaqueinstability. Arterioscler Thromb Vasc Biol, 2008, 28(12): 2108-14. 14 Hopps E, Caimi G. Matrix metalloproteases as a pharmacological target in cardiovascular diseases. Eur Rev Med Pharmacol Sci, 2015, 19(14): 2583-9. 15 Page K, Hughes VS, Bennett GW, et al. German cockroach proteases regulate matrix metalloproteinase-9 in human bronchial epithelial cells. Allergy, 2006, 61(8): 988-95. 16 Chiu HY, Chen CW, Lin HT, et al. Study of gastric fluid induced cytokine and chemokine expression in airway smooth muscle cells and airway remodeling. Cytokine, 2011, 56(3): 726-31. 17 Barbaro MP, Spanevello A, Palladino GP, et al. Exhaled matrix metalloproteinase-9 (MMP-9) in different biological phenotypes of asthma. Eur J Intern Med, 2014, 25(1): 92-6. 18 Felsen CN, Savariar EN, Whitney M, et al. Detection and monitoring of localized matrix metalloproteinase upregulation in a murine model of asthma. Am J Physiol Lung Cell Mol Physiol, 2014, 306(8): L764-74. 19 Sands MF. Localization of matrix metalloproteinase (MMP)-9 in lung tissue of a murine model of allergic asthma. Immunol Invest, 2012, 41(1): 87-96. 20 Karakoc GB, Yukselen A, Yilmaz M, et al. Exhaled breath condensate MMP-9 level and its relationship wıth asthma severity and interleukin-4/10 levels in children. Ann Allergy Asthma Immunol, 2012, 108(5): 300-4. |
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