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| Final Overall Survival Results from the FLAURA Trial: a Phase III Study on Osimertinib in EGFRMutated Advanced Non-small Cell Lung Cancer |
| Yue WANG, Juan NAN |
| Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300054, China |
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Abstract The discovery of activating mutations in epidermal growth factor receptor (EGFR) and development of first-/secondgeneration EGFR-tyrosine kinase inhibitors (TKIs) against EGFR sensitive mutations have contributed to a paradigm shift in the treatment of non-small cell lung cancer (NSCLC). However, drug resistance greatly limits the long-term efficacy of EGFRTKIs. Osimertinib, a third-generation EGFR-TKI, has shown efficacy not only in NSCLC patients who are resistant to firstand second-generation EGFR-TKIs but also in patients with central nervous system metastases. On November 21, 2019, the
investigators of the FLAURA trial reported that the NSCLC patients with EGFR mutation who were treated with osimertinib had longer progression-free survival (PFS) than those treated with comparator EGFR-TKIs. However, the data maturity on overall survival (OS) was very low at the time of the primary analysis. In the latest report recently published in The New England Journal of Medicine, the FLAURA team reported the final results of the OS data. They found that first-line osimertinib was associated with significantly longer OS, as compared with comparator regimen, in treating patients with EGFR-mutated advanced NSCLC.
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Corresponding Authors:
Juan NAN, E-mail: nanj1212@163.com
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