Journal of International Translational Medicine
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Journal of International Translational Medicine
Journal of International Translational Medicine
JITM, ISSN 2227-6394
founded in 2012
Editor-in-chief:Feng Jifeng, China
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Efficacy of a Condom Negotiation Intervention among High Risk Iranian Women in Tehran, Iran
Zahra Bayat JOZANI, SeyedAhmad SEYEDALINAGHI, Saeedeh MOAYEDI-NIA, Mohadese BEHTAJ, Mostafa SHOKOOHI, Minoo MOHRAZ, Farzaneh VAKILI, Hoorvash Fraji DANA
Journal of International Translational Medicine, 2018, 6(3): 105-112
KRAS Gene Mutations in Relation to Development and Progression of Non-small Cell Lung Carcinoma in Indian Kashmiri Population

Naseer Ue Din SHAH, Md Niamat ALI, Syed MUDASSAR, Bashir A GANAI, Malik Tariq RASOOL, Mosin Saleem KHAN, Jasbir KOUR
Journal of International Translational Medicine, 2018, 6(3): 113-120
Effectiveness of Acceptance and Commitment Therapy on Reducing Depression among People Living with HIV/AIDS
Matin FAEZIPOUR, Afsaneh GHANBARIPANAH, SeyedAhmad SEYEDALINAGHI, Mahboubeh HAJIABDOLBAGHI, Fabricio VOLTARELLI
Journal of International Translational Medicine, 2018, 6(3): 125-129
Dosimetric Comparison between 9F-IMRT, Single Arc VMAT and Dual Arc VMAT for Postoperative Cervical Cancer Patients with Para-aortic Lymph Node Metastasis
Yaqin WU, Biqing ZHU, Jingjing HAN, Hanzi XU, Jian HUANG, Emei LU
Journal of International Translational Medicine, 2018, 6(3): 130-135
 
Current Issue Accepted Online First Archive Most Downloaded
  2018, 6(3)   Published: 30 September 2018
 
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Efficacy of a Condom Negotiation Intervention among High Risk Iranian Women in Tehran, Iran Hot!
Zahra Bayat JOZANI, SeyedAhmad SEYEDALINAGHI, Saeedeh MOAYEDI-NIA, Mohadese BEHTAJ, Mostafa SHOKOOHI, Minoo MOHRAZ, Farzaneh VAKILI, Hoorvash Fraji DANA
Journal of International Translational Medicine, 2018, 6(3): 105-112 | doi:10.11910/2227-6394.2018.06.03.01
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Background: Development of tailored interventions to promote condom use seems essential in countries with traditional gender role definitions. Learning condom influence strategies could be helpful when it is difficult for women to initiate sexual communication. These strategies have been targeted in a safer sex skills building intervention among high-risk women in Tehran, Iran.

Methods: We conducted this study among 50 high-risk women who registered for counseling and HIV testing at Imam Khomeini Hospital in Tehran, Iran, 2012-2013. Participants were assigned to two groups: 1) routine 15 minute pre-test HIV counseling, or 2) routine counseling besides communication skills building monthly sessions for six months. Pre and post-tests were taken at baseline and six months. We designed an intervention based on Information-Motivation-Behavior theory. Condom influence strategies were used in the construct of the questionnaire and intervention materials.

Results: After six months participants in the intervention group were able to implement influence strategies to promote partners’ condom use (P = 0.01). Risk information and relationship conceptualizing were more endorsed post-intervention (P = 0.02, P =0.006). In addition, partner communication had significantly improved in the case group (P < 0.001).

Conclusions: We found that condom influence strategies could be considered in improving current counseling sessions, as an effective intervention to minimize HIV and other Sexually Transmitted Infections (STIs) transmission among high-risk women. We recommend this skill-based intervention for condom negotiation to empower at-risk sexually active women.

KRAS Gene Mutations in Relation to Development and Progression of Non-small Cell Lung Carcinoma in Indian Kashmiri Population
Hot!
Naseer Ue Din SHAH, Md Niamat ALI, Syed MUDASSAR, Bashir A GANAI, Malik Tariq RASOOL, Mosin Saleem KHAN, Jasbir KOUR
Journal of International Translational Medicine, 2018, 6(3): 113-120 | doi:10.11910/2227-6394.2018.06.03.02
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Background:
The most common molecular alterations observed in non-small cell lung carcinoma (NSCLC) lie in the mutations of KRAS gene. In this study, we have screened prospectively all newly diagnosed patients with NSCLC (n = 70) and blood samples of these patients were collected from Sheri-I-Kashmir Institute of Medical Sciences (SKIMS).
Methods: Blood DNA was extracted and amplified by ASO PCR and finally sequenced to detect KRAS mutations.
Results: We found 30% prevalence of KRAS mutation rate of NSCLC in the Kashmiri population. The significant association was seen between KRAS gene mutation and histological types of lung cancer. The higher frequency was seen in ADC than SCC and show statistically significant difference (P < 0.01). Also the higher frequency of KRAS (exon 2) mutation was reported in NSCLC patients in advanced stage than the early stages. The difference was statistically significant (P < 0.05). A statistically significant difference was reported between smokers and non-smokers with respect to the KRAS (exon 2) mutation (P <0.01). The significantly higher frequency of this mutation was reported in NSCLC patients (29.16%) with metastasis (P < 0.03).
Conclusion: We finally found that KRAS (exon 2) mutation is a common molecular alteration in NSCLC and occurs most predominantly on codon 12, 13.
Hematologic and Hepatic Enzymes Abnormalities and Associated Factors among Patients with Swine Influenza (H1N1) Admitted in Two Hospitals, Tehran, 2014-2016
Saeedreza Jamali Moghadam SIYAHKALI, SeyedAhmad SEYEDALINAGHI, Omid DADRAS, Zoha ALI, Samira ARMANPOUR
Journal of International Translational Medicine, 2018, 6(3): 121-124 | doi:10.11910/2227-6394.2018.06.03.03
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Background:
Influenza A is a single-stranded ribonucleic acid (RNA) virus that belongs to orthomyxoviridae family. The virus usually invades the respiratory tract endothelium, and the period of contagiousness is up to 5 days after the onset of symptoms. Influenza is an important cause of lower respiratory tract infections (LRTIs) and approximately 8%-10% of all patients with pneumonia are positive for influenza. In this study, we aimed to evaluate hematologic and hepatic enzymes disorders in patients with swine influenza (H1N1) admitted in two hospitals, Tehran.
Methods: This is a cross-sectional study identifying the hematologic and hepatic enzymes abnormalities and influencing factors conducted among patients with swine influenza (H1N1) admitted in Imam Khomeini and Ziaeiyan Hospitals in 2014-2016. One hundred eighteen people with suspected or confirmed influenza were evaluated for hematologic and hepatic enzymes disorders.
Results: In this study, the total number of individuals was 118, including 58 (49%) women and 60 (51%) men. Thirty-seven (31%) of patients had pneumonia, 51 (43%) of them had hypertension and diabetes, 5 (5%) of them expired. PCR of 28 (33%) nasopharynx samples were positive. The mean ratio of neutrophil to lymphocyte at the time of admission was 3.4 and the mean ratio of neutrophil to lymphocyte at the time of discharge was 2.1, which indicated lymphopenia.
Conclusion: H1N1 is associated with more hematologic and liver enzyme abnormalities than non-H1N1 subtypes thus if we notice these changes on lab tests, we should suspect more to H1N1 than non-H1N1.
Effectiveness of Acceptance and Commitment Therapy on Reducing Depression among People Living with HIV/AIDS Hot!
Matin FAEZIPOUR, Afsaneh GHANBARIPANAH, SeyedAhmad SEYEDALINAGHI, Mahboubeh HAJIABDOLBAGHI, Fabricio VOLTARELLI
Journal of International Translational Medicine, 2018, 6(3): 125-129 | doi:10.11910/2227-6394.2018.06.03.04
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Background:
Depression is prevalent among People Living with HIV/AIDS (PLHA). Reducing depression is effective in improving health care and it slows down the progression of the infection.
Objectives: We aimed to determine the effectiveness of Acceptance and Commitment Therapy (ACT) on reducing depression in HIV/AIDS patients.
Methods: This quasi-experimental study was performed through pretest-posttest with the experimental and control groups. The study population consist of all HIV/AIDS patients who referred to Imam Khomeini Hospital in 2016. Twenty four patients (16 men and 8 women) were selected by convenience sampling and assigned to the experimental and control groups. All the participants were evaluated in the first and last session by Bech Depression Inventory (BDI-II). Participants supposed to get at least 14 scores in the BDI-II and they must had mild depression. The experimental group received eight training sessions of ACT that each lasted 60 minutes. The control group received no intervention. In order to determine the effectiveness of ACT, the results of pretest and posttest were compared together. Data analyses were conducted by SPSS (version 21).
Results: According to the results, mean of depression scores was reduced in posttest in the experimental group. However, there was no significant difference in scores of the control group. The one way covariance analysis showed a significant difference in depression scores in the experimental group compared to the control group (P = 0.004). 
Conclusions: The study indicated that acceptance and commitment therapy is an effective approach on reducing depression among PLHA.
Dosimetric Comparison between 9F-IMRT, Single Arc VMAT and Dual Arc VMAT for Postoperative Cervical Cancer Patients with Para-aortic Lymph Node Metastasis Hot!
Yaqin WU, Biqing ZHU, Jingjing HAN, Hanzi XU, Jian HUANG, Emei LU
Journal of International Translational Medicine, 2018, 6(3): 130-135 | doi:10.11910/2227-6394.2018.06.03.05
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Background: The aim of this study was to compare the dosimetric parameters of 9 field intensity modulated radiotherapy (9F-IMRT) and two kinds of volumetric modulated arc therapy (VMAT) for postoperative cervical cancer patients with paraaortic lymph node (PALN) metastasis, and to provide the reasonable selection of the cervical cancer patients with para-aortic lymph node metastasis who need postoperative radiotherapy in clinic.
Methods: Fifteen patients of postoperative cervical cancer patients with para-aortic lymph node metastasis were planed with the same dose prescription and optimization parameters by means of 9-field IMRT (9F-IMRT), a single arc (Arcl) and dual arc (Arc2) VMAT, respectively. The dosimetric differences of planning target volume (PTV), organs at risk(OAR), the number of monitor units (MUs) and treatment time were compared among the three treatment plans.
Results: The conformity index (CI) and the homogeneity index (HI) of PTV for Arc2 plans were superior to 9F-IMRT (P <0.05). The V40, V50 of the rectum, V50 of the intestine, bladder and femoral head for Arc2 plans were better than 9F-IMRT plans. V50 of the femoral head and the mean dose of kidney for Arc1 and Arc2 plans were all better than 9F-IMRT plans. The number of MUs of 9F-IMRT plans (1,105.27 ± 107.12) was significantly higher than the Arc1 plans (755.23 ± 225.98) and Arc2 plans (967.24 ± 198.41), the difference was statistically significant (F = 12.736, P < 0.01). The treatment time of 9F-IMRT plans (430.47 ± 36.45) was significantly higher than the Arc1 plans (304.20 ± 48.42) and Arc2 plans (332.93 ± 47.62), the difference was statistically significant (F = 33.180, P < 0.01).
Conclusion: Compared to 9F-IMRT, Arc1 and Arc2 plans can better to meet the clinical requirements for the postoperative cervical cancer patients with para-aortic lymph node metastasis. And the Arc2 VMAT plans is superior to Arc1 VMAT plans, there will significantly improve the treatment efficiency.

Cognitive, Immunologic, Virologic, Functional, and Demographic Predictors of Health-related Quality of Life in People Living with HIV
Saeed GHODRATI, Zahra SHAHABINEZHAD, SeyedAhmad SEYEDALINAGHI, Nadia SADEGHI, Kazem Baesi, Fabricio VOLTARELLI
Journal of International Translational Medicine, 2018, 6(3): 136-140 | doi:10.11910/2227-6394.2018.06.03.06
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Background:
With recent progress in the treatment of people living with HIV (PLWH) and increasing their survival, quality of life has received highly attention. In the present study, we aimed to investigate the cognitive, immunologic, virologic, functional, and demographic predictors of health-related quality of life in people living with HIV.
Methods: The study sample was comprised of 67 HIV-infected individuals who were under treatment of anti-retroviral therapy (ART) in Imam Khomeini Hospital of Iran, Tehran in 2016. We used correlation and step-wise regression to data analysis using SPSS-22 software.
Results: The findings of stepwise regression analysis showed that prospective/retrospective memory complaint and daily life functioning were predictors of health-related quality of life in PLWH [P < 0.001, F (2,64) = 18.90, R2 adj = 0.520]. The results also showed that CD4 cell count, viral load, gender, age, and education were not predictors of health-related quality of life in PLWH (P > 0.05).
Conclusion: The present article showed that prospective/retrospective memory complaint was a strong predictor of healthrelated quality of life in PLWH. Daily life functioning was another predictor of health-related quality of life. Considering that people living with HIV live longer with this chronic illness, knowing factors related to HRQoL plays a prominent role in survival and well-being of PLWH.
Evaluation of Sensitivity and Specificity of the Method Cefoxitin-disk Diffusion in Detection of Methicillin-resistant Staphylococcus Aureus in Clinical Samples of Two Hospitals, Tehran, Iran
Saeedreza Jamali Moghadam SIYAHKALI, Omid DADRAS, Zoha ALI, SeyedAhmad SEYEDALINAGHI, Nilofar HEJAZI
Journal of International Translational Medicine, 2018, 6(3): 141-143 | doi:10.11910/2227-6394.2018.06.03.07
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Background:
The rapid growing rate of Methicillin-resistant Staphylococcus aureus (MRSA) infection is a noticeable phenomenon worldwide and has become a global concern of substantial emphasis. A reliable, accurate and rapid test for the detection of MRSA is important for both therapeutic as well as control measures. This study aimed at comparing the phenotypic (disk diffusion) and genotypic (polymerase chain reaction) methods for the expeditious diagnosis of methicillin-resistant strain samples isolated from patients admitted at Tehran Central Hospitals.
Materials and methods: Through a cross-sectional study a total of 150 samples were collected and tested from the patients admitted at Tehran hospitals located in central Tehran between 2014-2015. The isolated samples sensitivity to Cefoxitin disks was confirmed through disk diffusion. Polymerase chain reaction (PCR) method was performed as the “Gold Standard” test to identify the specimens with mecA gene presence. Results were compared based on sensitivity and specificity by application of chi-square test in SPSS software (version 22).
Results: Eighty-three percent of 150 collected samples tested resistance for Cefoxitin applying Cefoxitin disk diffusion method. Three of the resistant samples to Cefoxitin were negative for the mecA gene; whereas 80% of the samples were proven positive for mecA gene using PCR. Sensitivity, specificity and positive and negative predictive values of disk diffusion in comparison to PCR were 100%, 85%, 96% and 100%, respectively.
Conclusion: Findings indicated that Cefoxitin disk diffusion method is a simple phenotypic method; however, it has an acceptable sensitivity compared to the PCR method. Therefore, it is recommended for the detection of MRSA. The existence of strains resistant to Cefoxitin without mecA gene suggests the emergence of either a new resistance strain or mutation in MRSA.
Care Coordination for Lung Biopsy Combined with Brush Biopsy and Bronchoalveolar Lavage with Electromagnetic Navigation Bronchoscopy: A Report of 6 Cases
Jing LI, Hongxiang XIA, Ying LOU, Xiaoxu ZHI, Changmin MAO
Journal of International Translational Medicine, 2018, 6(3): 144-146 | doi:10.11910/2227-6394.2018.06.03.08
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Background: To explore the care cooperation and experience of lung biopsy combined with brush biopsy and bronchoalveolar lavage with electromagnetic navigation bronchoscopy (ENB).
Methods: The experience was summarized by reviewing the clinical data and preoperative preparation, nursing coordination and postoperative health guidance of 6 patients for ENB. The therapeutic effects were evaluated.
Results: All cases were successfully completed. 4 patients were malignant cases, 3 cases of them underwent video-assisted thoracoscopic surgery, and 1 patient underwent radiotherapy and other multimodality therapy. The other 2 cases were benign cases. No complications occurred during hospitalization.
Conclusion: Lung biopsy combined with brush biopsy and lavage with electromagnetic navigation bronchoscopy needs skilled care cooperation, which is beneficial to improve the positive rate of biopsy in peripheral pulmonary nodules.
Journal of International Translational Medicine
 
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