Interpretations of Chemotherapeutic Protocols on Small Cell Lung Cancer Hot!
Brief Introduction of NCCN Clinical Practice Guidelines for Adolescent and Young Adult Oncology Hot!
Upregulation of Renin-Angiotensin System in Bone Marrow Mesenchymal Stem Cells Under Hypoxia Conditions Hot!
Inhibiting Effect and Its Mechanism of Ibandronate on the Proliferation of Humanized NSCLC A549 Cells in Vitro Hot!
Establishment and Identification of Chinese Hamster Ovary Cell Lines with Stable Expression of Soluble CD40 Ligands#br# Hot!
Effect of Evodiamine on Inducing Apoptosis of Human Gastric Cancer Cell Line SGC-7901 in Vitro Hot!
Suppressive Effect of Icaritin on Angiogenesis and Its Mechanisms Hot!
Clinical Application of Total Knee Arthroplasty on Patients with Advanced Knee Osteoarthritis#br# Hot!
Analysis of Positive Human Immunodeficiency Virus (1＋2) Antibodies in Preliminary Screening: A Report of 394 Cases Hot!
Expressions of Ezrin and CD44v6 in Gastric Cancer Hot!
Expressions of 11beta-Hydroxysteroid Dehydrogenase Types 1 and 2 in Human Colorectal Cancer Hot!
The Expression of Ezrin and Its Significance in Non-small Cell Lung Cancer Hot!
Terminal Cancer: Malignant Spinal Cord Compression and Full Code Status Hot!
An Acute Hemorrhagic Infectious Disease: Ebola Virus Disease Hot!
Review on Different Action Mechanisms of PDGF-BB on Glomerular Mesangial Cell Proliferation#br# Hot!
Platelet-derived growth factor BB (PDGF-BB) and PDGF receptor-β (PDGFR) play critical roles in proliferation and envolving into MsPGN of mesangial cells in embryonic development. The mechanisms can be demonstrated mainly from several aspects such as promoting the proliferation of glomerular mesangial cells (GMC), stimulating the GMC expression of extracellular matrix components and synergism with other growth factors like transform growth factor-β (TGF-β) and so on. As in the pathological development of mesangial proliferative lesions, GMCs is not only the victim of kidney damage but also the direct participants. GMCs can secrete excessive PDGF - BB and other growth factors which could react to GMCs, leading to malignant progress of kidney damage. Therefore, inhibiting GMCs over expression of PDGF-BB and blocking the effect of PDGF-BB on promoting proliferation and ECM accumulation is undoubtedly an effective way to delay kidney damage.
Exerting the Role of Journal of International Translational Medicine in Translational Medicine Hot!