Expression of Caspase-3 in Laryngeal Squamous Cell Carcinoma and its Relationship with Cell Apoptosis
Expression of p16 in Human Colorectal Cancer and Its Clinical Significance Hot!
Application of 18F-FDG PET/CT in Rare Metastatic Locations of Esophageal Carcinoma Hot!
Translational Medicine Study on Circulating Tumor Cell Detection in Patients with Metastatic Breast Cancer Hot!
Relationship between Polymorphism of HLA-DP Gene and Susceptibility Hepatitis C Infection Hot!
Objective: To assess the relationship between HLA-DP gene polymorphism and the susceptibility of HCV infection among high-risk populations in Jiangsu Province. Methods: Three HLA-DP variants of rs3077, rs9277535 and rs2395309 were genotyped in 1653 subjects including 268 self-limited HCV infection subjects, 401 persistent HCV infection subjects and 984 healthy control people using Taqman- MGB. Conclusion: These variants in the HLA-DP locus are associated with the susceptibility of HCV infection.Three HLA-DP variants of rs3077, rs9277535 and rs2395309 were genotyped in 1653 subjects including 268 self-limited HCV infection subjects, 401 persistent HCV infection subjects and 984 healthy control people using Taqman- MGB. Results: The frequencies of rs3077, rs9277535 and rs2395309 mutant genotype in HCV infected group were much higher than in control group (Prs3077<0.010; Prs9277535=0.043; Prs2395309<0.010); The frequencies of rs3077 TC and rs2395309 AG heterozygous genotypes were much higher than control group (Prs3077=0.033
Effect of Psychological Factors on the Level of Serum Vascular Endothelial Growth Factor in Patients with Gynecological Malignant Tumors
Comparative Study on Rituximab Combined with Chemotherapy and Single Chemotherapy for Diffuse Large B Cell Lymphoma Hot!
Application of Translational Medicine Theory in Chinese Materia Medica: Effect and Mechanism of Mahuang and Wuweizi on Pulmonary Fibrosis Hot!
Metabolic Alkalosis: A Real Danger of Overdiuresis in Patients with Heart Failure
Targeted Therapies for Inflammatory Bowel Disease and Colorectal Cancer: An Increasing Need for Microbiota-Intestine Mutualism
The involvement of intestinal microbiota and dysbiosis in the pathogenesis of inflammatory bowel disease (IBD) and colorectal cancer (CRC) is a well-established fact to be taken into real consideration when developing tartgeted therapies. This review aimed to depict what advances in our understanding of the role of intestinal flora in the pathogenesis of IBD and CRC is shaping up the therapeutic protocols of their management. It was demonstrated that there is a circadian regulation of colocytes gene expression in response to microbiota. In addition, dysbiosis leading to a decrease in microbiome biodiversity was also described in IBD patients whereby thick layers of adherent mucosa associated bacteria exist both in ulcerative colitis (UC) and Crohn’s disease (CD). Probiotics based approaches using lactobacilli and Bibidobacteria improved clinical symptoms of IBD’s through the GALT immune modulation. In addition, fecal microbiota transplantation (FMT) has also been used for IBD treatment. It consists of transferring gastrointestinal microbiota from a healthy donor to an IBD patient by duodenal infusion of liquid stool suspension to establish microbial homeostasis. The passage of bacteria in the injured mucosal zone triggers chronic inflammation and eventually CRC development by creating a carcinogenic environment. Actually, high level of Fusobacterium nucleatun and other bacteria are prevalent in CRC patients, thus suggesting a potential role of these organisms in the initiation and progression processes due to the production of genotoxic metabolites causing a direct damage to DNA integrity. Moreover, regular probiotics intake was shown to actively prevent the whole process. In conclusion, the mutualistic relationship between microbiota and colonic mucosa proved useful in depicting some of the dynamics of the initiation and development of IBD and CRC. Therapies oriented towards establishing equilibrium of intestinal microbiota may represent the key strategy to switch off chronic inflammatory processes hitting colonic mucosa, thus preventing the onset of CRC.
Exploration of Disease Markers under Translational Medicine Model
Application of Metabonomics in Early Diagnosis of Diseases Hot!
Interpretation of NCCN Guidelines: General Therapies on Non-small Cell Lung Cancer (Version 6. 2015) Hot!