Analysis of Imaging Characteristics of 18F-FDG PET/CT in Misdiagnosed Bone Tuberculosis: A Report of 12 Cases
Objective: To analyze the imaging characteristics of 18F-fluorodeoxyglucose positron emission tomography/computer tomography (18F-FDG PET/CT) in 12 cases of misdiagnosed bone tuberculosis so as to explore the differential diagnostic method with metastatic bone tumors.
Methods: The images of 12 patients with bone tuberculosis diagnosed by 18F-FDG PET/CT were retrospectively analyzed. Distribution of lesion locations in the whole body and characteristics of glucose metabolism were analyzed by qualitative and semi-quantitative methods, especially for bone lesion location, number and range, glucose uptake form and CT imaging characteristics, and the maximum of standardized uptake value (SUVmax) was measured and recorded.
Results: Of 12 patients, 1 showed increased glucose uptake of diffuse bone marrow in the whole body, whereas the rest suffered from 19 bone lesions, in which each one had 1 bone lesion in 9 cases, accounting for 75.0%. The images of PET/CT in 12 patients primarily manifested annular or nonuniform increase of glucose uptake (63.2%), sequestrum within osteolytic lesions (31.6%), injured intervertebral disc caused by vertebral lesions (61.5%) and cold abscesses around the lesions (68.4%). The glucose uptake rate of cold abscesses was higher than that of bone lesion locations. The tuberculosis complicated with other parts included lymphatic tuberculosis (100.0%), pulmonary tuberculosis (66.7%), pericardial or pleural tuberculosis (25.0%) and hepatolienal tuberculosis (8.3%).
Conclusion: The characteristics of bone tuberculosis lesions are prominent in 18F-FDG PET/CT imaging, which could contribute to diagnosis of whole body tuberculosis and has a greater value in the differentiation of bone tuberculosis and metastatic bone tumors.
Clinical Study of S-1 Plus Oxaliplatin Versus S-1 Plus Cisplatin as First-Line Treatment for Elderly Patients with Advanced Gastric Cancer
Efficacy of Argentum-Quartz Solution in the Treatment of Perianal Fistulas: A Preliminary Study Hot!
Translational Research on Epidermal Growth Factor Receptor Gene Mutations in Targeted Therapy for Patients with Advanced Non-Small Cell Lung Cancer Hot!
Correlation Between Th1, Th2 Cells and Levels of Serum MMP-2, MMP-9 in Children with Asthma Hot!
Comparison of Active Ingredient Content of Nanwuweizi and Beiwuweizi Collected in Different Seasons Detected by HPLC-DAD Hot!
Influence of Depressive State on Levels of Homocysteine and Thyroid Hormone in Patients with Hypertension Hot!
Objective: To explore the influence of depressive state on the levels of homocysteine (Hcy) and thyroid hormone in patients with hypertension.
Methods: Totally 179 patients with primary hypertension were selected and divided into depression group (n=97) and non-depression group (n=82) according to whether to be complicated with depressive disorder. The venous blood was drawn for detecting the level of Hcy of 2 groups by enzymatic cycling assay, and serum free triiodothyronine (FT3), free thyroxine (FT4) and thyrotropic hormone (TSH) by chemiluminiscence. The correlation between Hamilton depression scale (HAMD) scores and levels of plasma Hcy and serum FT3, FT4 and TSH was analyzed.
Results: Compared with non-depression group, the level of plasma Hcy increased and the levels of FT3 and FT4 decreased in depression group (P<0.05), but there was no statistical difference between 2 groups (P>0.05). HAMD scores in depression group had a positive correlation with the level of plasma Hcy (r=0.593, P=0.024), a negative correlation with the level of serum FT3 (r=-0.421，P=0.011), and no relationships with the levels of serum FT4 and TSH (r=-0.137, P=0.334; r=0.058, P=0.576).
Conclusion: Hypertensive patients complicated with depression have abnormal level of Hcy and thyroid hormones. Moreover, the depressive degree of patients is positively correlated with the level of Hcy and negatively with the level of FT3.
Effect of Intrahepatic Cholestasis of Pregnancy on Cytokines, Hemorheology and Coagulation Function of Pregnant Women
Practices of Translational Medicine in Chinese Herbal Compound: Study on Pharmacological Material Basis of Qingganning Tablet based on HPLC Hot!
Translational Research in Enteral and Parenteral Nutrition Support for Patients with Severe Head Injury Hot!
Systematic Evaluation on Clinical Efficacy of External Application of Traditional Chinese Medicine in Treatment of Breast Hyperplasia
Advances in Targeted Therapy of Lymphoma Hot!
Research Advances of Atherosclerosis in Translational Medicine
Atherosclerotic cardiovascular diseases (ASCVD) are defined as a series of diseases caused by atherosclerosis (AS), including coronary heart disease (CHD), myocardial infarction (MI), stable or unstable angina pectoris, revascularization of coronary artery or other arteries, stroke, transient cerebral ischemic onset or atherosclerotic peripheral arterial disease. AS has common pathological basis with ASCVD as it is a general arterial regressive disease of human beings. With the industrialization progression, AS morbidity increases annually and it also leads to coronary atherosclerotic heart disease, cerebral stroke and peripheral artery stenosed occlusion or dilation, thus becoming the main cause for high disability and mortality. The main purpose of translational medicine is to break the intrinsic barrier between basic medicine with drug research and development as well as clinical and public healthcare, and establish a direct connection between them. It is also can rapidly transform basic research results to new clinical preventive and therapeutic methods. This study mainly reviewed AS from the aspect of translational medicine, aiming to provide a reliable basis for the prevention and treatment of AS.
Exosomes and Their Significance in Diagnosis and Treatment of Tumors