Advances in Translational Medicine of Liver Regeneration-Associated Regulatory Factors
Endoplasmic Reticulum Stress in Reproductive Function Hot!
Current Status and Progression of Endocrinotherapy for Prostate Cancer in the View of Translational Medicine
Influence of Neoadjuvant CAF Chemotherapy on Serum TSGF, CA15-3 and CA125 in Patients with Breast Cancer Hot!
The Expression and Significance of Interleukin-9, Interleukin-6 and Tumor Necrosis Factor-α in Colonic Mucosa of Patients with Ulcerative Colitis Hot!
Objective: To investigate the expression and significance of interleukin (IL)-9, IL-6 and tumor necrosis factor-α (TNF-α) in colonic mucosa of patients with ulcerative colitis (UC).
Methods: The expression levels of IL-9, IL-6 and TNF-α in colonic mucosa were detected by immunohistochemistry in 60 patients with UC (38 with mild UC and 22 with moderate-severe UC), and in 20 controls. To explore whether there were some influence from the age and gender, we further divided these 60 patients into <20 years group, 20-49 years group, and >49 years.
Results: The percentage of positive cells of IL-9 in colonic mucosa of moderate-severe UC group was significantly higher than that in mild UC group (P<0.05), IL-9 of mild group was higher than that of control group (P<0.01), and the expression levels of IL-6 and TNF-α had the same tendency as that of IL-9. For UC patients, the percentage of IL-9 positive cells in 20-49 years old group (85.0%) was higher than that in ≤20 years group (0.0%) or ≥49 years group (58.8%), and significant differences were shown. The percentage of the TNF-α positive cells in moderate-severe UC group (81.8%) was higher than that in mild UC group (51.3%) (P<0.05), which was also evidently higher in mild group than that in control group (5.0%) (P<0.01). The percentage of TNF-α positive cells in 20-49 years UC group (75.0%) was higher than that in <20 years UC group (67.6%), and the difference was statistically significant. There was no significant difference in the percentage of IL-9, IL-6, and TNF-α positive cells between females (75.0%) and males (72.7%) (P>0.05).
Conclusion: The expression levels of IL-9, IL-6 and TNF-α in colonic mucosa of UC are higher than those in the controls, and are all related to the severity of UC. It is speculated that IL-9, IL-6 and TNF-α play important roles in UC occurrence and development.
Study on the Influencing Factors of Blood Pressure Variability in Patients Undergoing Maintenance Hemodialysis
Antiviral Effects of Different Nucleos(t)ide Antiviral Drugs in Patients with Decompensated Hepatitis B Virus-Related Cirrhosis
Translational Study on the Relationships Between Body Mass Index, Levels of Serum Inflammatory Factors and Bronchial Asthma in Children
The Value of Soluble CD146 in the Diagnosis of Ovarian Cancer
Objective: To study the possible diagnostic value of soluble CD146 (sCD146) in patients with ovarian cancer.
Methods: A total of 33 patients with benign ovarian tumor and 30 with ovarian cancer from Department of Obstetrics and Gynecology, Anzhen Hospital were respectively selected as observation group A and observation group B, while 31 healthy women from Medical Center, Anzhen Hospital were served as control group. There was no significant difference in the age among three groups. Enzyme immunoassay and chemiluminescence were used to detect the expression of sCD146 and CA125, respectively.
Results: The sCD146 level was lower in observation group A and observation group B when compared with control group (P<0.01). Moreover, serum sCD146 in observation group B was further lower than that in observation group A (P<0.05). The CA125 level increased in observation group B compared with those in control group and observation group A (P<0.001). And the CA125 level in observation group A was markedly higher than that in control group, and the difference was statistically significant (P<0.001). If either single target was tested to be positive, it was advisable to choose combined detection of CA125 and sCD146, which could improve the diagnostic specificity.
Conclusion: sCD146 may provide a potential marker for the diagnosis and treatment of patients with ovarian cancer.
Clinical Features and Genetic Analysis of Tuberous Sclerosis Complex in a Chinese Family Caused by c.2677-2678del Mutation on TSC2 Gene Hot!
Interpretation on Expert Consensus for Diagnosis and Treatment of Melanoma in China