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Journal of International Translational Medicine
Journal of International Translational Medicine
JITM, ISSN 2227-6394
founded in 2012
Editor-in-chief:Feng Jifeng, China
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2018 Vol. 6, No. 4
Published: 29 December 2018

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Treatment Outcomes of Breast Cancer Oligometastatic to Lung and Liver: A Systematic Review and Meta-analysis Hot!

Roshni SINGH, Tabassum WADASADAWALA, Pallavi RANE, Gourab CHOWDHURY, Sadhana KANNAN, Rajiv SARIN
Journal of International Translational Medicine, 2018, 6(4): 147-158 | doi:10.11910/2227-6394.2018.06.04.01
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We conducted a systematic review of literature and meta-analysis for the studies on local treatment modalities for breast cancer oligometastases (OM) to lung and liver. The objective of the current study was to report survival outcome following optimal local treatment for OM in breast cancer. This would help in baseline assumptions for survival estimates for future prospective trials as well as provide guidelines for patient counselling in clinical practice.


Comparing Social Problem Solving Ability, Copying Styles and Risk-Taking Behaviors between People lving with HIV and Healthy Individuals, Tehran,Iran Hot!

Journal of International Translational Medicine, 2018, 6(4): 159-166 | doi:10.11910/2227-6394.2018.06.04.02
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Background: The present study aimed to compare social problem solving ability, coping with stressful situation and risk-taking behaviors among people living with HIV (PLWH) and healthy individuals in Tehran, Iran, 2013.

Methods: In the study, 50 patients aged 20 to 45 years living with HIV were assessed in Valfajr health center in Tehran, 2013.Moreover, 50 healthy individuals considered as the control group. To evaluate the ability to solve a social problem, standard questionnaires were used for social problem solving, coping for stressful situation and assessing the risk-taking. Data analyses were done by MANOVA test and independent T-test.

Results: The results showed that there was significant difference in social problem solving ability, coping inventory for stressful situation and risk-taking behaviors between the PLWH and the healthy individuals. Moreover, there was significant difference in all of subscales social problem solving ability (positive problem orientation, negative problem orientation, rational problem solving, impulsivity/carelessness and avoidant style). There was significant difference in all of subscales coping inventory for stressful situation (problem oriented coping, excitement oriented coping, avoidance coping and attention handling) but there is no significant difference found in social entertainment among the two groups. Furthermore, there was not seen any differences in the rate of risk taking between the two groups.

Conclusion: PLWH in social problem solving are using the negative problem orientation, impulsivity/careless style and avoidance style more than healthy individuals, this people mostly use emotional and avoidance-coping in stressful situation and also have more risk than the healthy individuals in their life.


Application of Twitter and Web News Mining in Monitoring and Documentation of Communicable Diseases   Hot!

Journal of International Translational Medicine, 2018, 6(4): 167-175 | doi:10.11910/2227-6394.2018.06.04.03
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Background: This study aimed to develop a method for extracting information concerning communicable diseases from Twitter and news websites.

Methods: Using an evolving fuzzy model as the basis of work, we developed the “Fuzzy Algorithm for Extraction, Monitoring,and Classification of Communicable Diseases (FAEMC-CD)". In addition to the real-time classification of input data, the method is able to update its vocabulary to include new keywords and visualize the classified data on a map to facilitate the

monitoring of disease data.

Significant findings: In a test implementation, 1,235 malaria-related tweets posted by 1,646 users in a 34-day period from 05/06/2018 to 09/07/2018 were examined. Divided by country, the number of malaria-related tweets ranged from 1 to 166, with the highest number (166) belonging to Nigeria. The origins of malaria-related news were mostly located in Africa, South America, and India.

Conclusion: A performance analysis of the developed method in comparison with the existing algorithms showed the high accuracy of the method with a recall ratio of 89.5% and the high intra-class correlation of its outputs. The method can also be used to monitor other diseases and for documentation and monitoring in other areas of medicine, paramedicine, and health sciences.



Epidemiological and Clinical Information of People At Risk for HIV Referred to the Voluntary Counseling and Testing Center, Tehran, Iran, 2013-2014 Hot!

Journal of International Translational Medicine, 2018, 6(4): 176-180 | doi:10.11910/2227-6394.2018.06.04.04
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Background: As the effective treatment can control the HIV progression and also, there is possibility of prevention after exposure, investigation of people at risk for HIV would be useful. Patient adherence to post exposure prophylaxis (PEP) was estimated 59.6% in Iran and the main reason for discontinued PEP was negative serological test result of the source person. The aim of this cross-sectional study was to assess the epidemiologic, and clinical information of individuals, who were referred to the voluntary counseling and testing (VCT) center of Imam Khomeini Hospital during 2013 to 2014.

Methods: In a study conducted in Tehran during 2013 to 2014, included 453 people who were eligible for receiving antiretroviral drugs as PEP were assessed. We designed a questionnaire regarding socio-demographic and antiretroviral therapy (ART) regimen.

Results: From a total of 453 adult people who enrolled in this study, 274 (60.5%) subjects complete PEP course while other 179 (39.5%) individuals did not complete PEP regimen. Investigating the reasons of incomplete PEP revealed that 11 (6.1%) subjects could not afford the drug regimen, 83 (46.4%) persons did not return to the center for completing PEP course, three (1.7%) subjects discontinued the PEP program for adverse event of drug reactions containing nausea and vomiting in two persons and rash in one of the participants, 64 (35.7%) persons interrupted the PEP course because of the negative serological test result of the source person. Moreover, in 18 (10.1%) persons the reason was not defined. After six months, 116 people returned to the center and all of 116 persons had negative HIV Ab test result.

Conclusions: We recommend adherence counseling for the people in order to complete the PEP course and to increase adherence to the treatment.


  Classification of Esophageal Motility Disorders in Patients Referring to Hospital Manometric Unit

Journal of International Translational Medicine, 2018, 6(4): 181-184 | doi:10.11910/2227-6394.2018.06.04.05
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Background: Esophageal motility disorders can be a cause of dysphagia and chest pain. Esophageal high-resolution manometry (HRM) is the latest diagnostic method to investigate esophageal disorder. Therefore, the aim of this study was to investigate the clinical symptoms of patients with other esophageal motility disorders (without achalasia) in comparison with patients suffering from achalasia. Because timely diagnosis and treatment leads to preservation of remaining esophageal movements, which can be helpful in reducing the disease.

Methods: This descriptive cross-sectional studywas conducted on 1,315 patients who suffered from dysphagia and chest pain with non-cardiac origin and refractory reflux disease, which were also excluded from organic diseases for 10 consecutive years. Data was analyzed using IBM SPSS 19 Statistic software.

Results: Among all enrolled patients, 51.18% were males and the highest age group belonged to 35 and 40 years old. Among esophageal motility disorders, type 2, achalasia was the most frequently detected type (26.77%), while the least disorder (0.7%) was related to functional obstruction.

Conclusion: Esophageal motility disorders account for a significant percentage of elderly patients. Clinical symptoms cannot always differentiate different types of esophageal motility disorders; therefore, esophageal manometry is necessary in diagnosing and determining the type of treatment for these disorders.


A 51-year-old Iranian Woman with Chronic HBV Infection with Reversible Cirrhosis after Tenofovir Therapy

Journal of International Translational Medicine, 2018, 6(4): 185-187 | doi:10.11910/2227-6394.2018.06.04.06
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Little data exist on patients treated with tenofovir and reversible cirrhosis in Iran. A 51-year-old Iranian woman with chronic HBV infection and positive serum hepatitis B surface antigen (HBsAg) presented with abnormal liver function tests. Because of severe fibrosis that was reported in liver biopsy, received adefovir 10 mg daily. Forty-eight months after the commencement of adefovir, because of resistance, Tenofovir 300 mg daily was started. In the 4 years following commencement of Tenofovir patient’s physical examinations, gastrointestinal endoscopy and abdominal ultrasonography were unremarkable. Also, the cirrhosis was reversed and confirmed with liver biopsy. Our findings are indicating histopathological improvement in cirrhosis is achievable through sustainable viral repression of HBV with Tenofovir.


A Myeloid Sarcoma Presenting as Acute Pancreatitis in a Previously Healthy Patient without Any Visible Pancreatic Mass on Computed Tomography

Journal of International Translational Medicine, 2018, 6(4): 188-190 | doi:10.11910/2227-6394.2018.06.04.07
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We describe a previously healthy girl presented with acute pancreatitis without any evidence of gallstones or mass formation on computed tomography or transabdominal ultrasonography. Myeloid sarcoma finally diagnosed based on immunophenotyping of pancreas tissue, ascites and pleural fluid by flow cytometry. Bone marrow aspirate cytometry was unremarkable.


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