Targeting Metabolism of Cancer Stem Cells: A New Therapeutic Window Opens
A Practical Approach for Nodal Classification of Gastric Cancer with Limited and Adequate Number of Lymph Nodes
Dysregulated Metabolic Enzyme Drives Tumor Initiation by Inducing Epigenetic Alterations
Serum Copper and Zinc Concentrations in Patients with Acute Brucellosis Hot!
Purpose: Altered serum concentrations of Zinc (Zn) and Copper (Cu) has been defined in infectious and inflammatory diseases. The aim of this study was to evaluate serum Zn and Cu concentration and Cu/Zn ratio status in patients with brucellosis compared with healthy individuals.
Materials and methods: Serum Zn and Cu level of 36 patients with brucellosis (28 men and 8 women) were compared with those of 36 matched healthy controls. Serum micronutrient concentrations were measured by automatic absorption spectrophotometry.
Results: Serum Zn concentration was lower in patients with brucellosis than that of healthy individuals [(86.21 ± 31.99) µg/dL and (133.02 ± 85.66) µg/dL, respectively, P = 0.003]. Mean serum Cu concentration was significantly higher in subjects with brucellosis when compared with that of healthy controls [(249.92 ± 104.59) µg/dL and (89.0 ± 27.76) µg/dL, respectively, P< 0.001]. Copper/Zinc ratio was found to be significantly higher in patients with brucellosis than that of healthy individuals [(3.16 ± 1.58) and (0.83 ± 0.41), respectively, P < 0.001].
Conclusion: Serum Zn and Cu concentrations and Cu/Zn ratio later in patients with brucellosis during the period of infection. Further studies are needed to determine whether these micronutrients have an effect on disease severity and outcome.
Pre-labor Uterine Rupture with Abdominal Pain in a Pregnant Woman: A Case Report and Literature Review Hot!
Rupture of uterine is an important side effect of pregnancy for health policy in developing countries. It is a rare event that causes maternal mortality and fetal morbidity. A 27-year old woman in the gestational age of 23 weeks who was admitted to the hospital because of a vague abdominal pain for 5 days. Her previous ultrasound which was done two weeks later reported as an intrauterine fetus with normal umbilical cord and normal volume amniotic fluid. There was no sign of ectopic pregnancy. The patient recommended being evaluated by abdominal and pelvic magnetic resonance imaging with/without gadolinium. Magnetic resonance imaging (MRI) results showed normal position of the uterus opening in the cesarean scar. In subhepatic tissue, single fetus in transverse position on the anterior bowel loops was evident. On the serosal surface of the uterine fundus, a mixed signal with a size of 125×95 millimeters in favor of placenta was seen. After resuscitation with intravenous fluids, the patient was prepared for surgery. Emergency laparotomy was done. The patients with abdominal pain and vaginal bleeding during pregnancy who have this risk factor should be mentioned for uterine rupture as a critical differential diagnosis if the diagnosis is confirmed they should be a candidate for emergency laparotomy and massive transfusion and fluid resuscitation.